发明名称 |
Method for manufacturing stereoselective preparation of 4-bma using a chiral auxiliary and chiral auxiliary |
摘要 |
<p>The present invention relates to a process for preparing (3R,4S)-3- [[[R]-1 ' -t-butyldimethylsilyloxy ]ethyl]-4-[(R)-1 "-carboxyethyl]-2-azetidinone (beta- methylazetidin-2-one; 4-BMA), a key intermediate for the synthesis of carbapenem and penem antibiotics. Specifically, the present invention relates to a process comprising first, the preparation of a chiral auxiliary from cheap L-Phenylalaninol, and then the preparation of 4-BMA in high yield and high selectivity, under industrially mild condition.</p> |
申请公布号 |
EP2345645(A1) |
申请公布日期 |
2011.07.20 |
申请号 |
EP20090180507 |
申请日期 |
2009.12.22 |
申请人 |
SAVIOR LIFETEC CORPORATION |
发明人 |
TSENG, WEI-HONG;CHUANG, SHIUAN-TING;HUNG, ZUN-YUAN;WU, CHING-I |
分类号 |
C07D263/20;C07D413/06 |
主分类号 |
C07D263/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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