GUANOSINE TETRAPHOSPHATE SYNTHASE RELA AND THE COMPOSITIONS FOR INCREASING ANTIBIOTIC COMPRISING RELA

摘要

PURPOSE: A guanosine nucleotide biosynthetic relA gene of high phosphorylation is provided to induce natamycin expression and to cheaply produce natamycin antibiotics. CONSTITUTION: A guanosine nucleotide biosynthetic relA gene of high phosphorylation encodes a protein having an amino acid of sequence number 2. The gene has a base sequence of sequence number 1. relA protein has an amino acid sequence of sequence number 2. A recombinant vector, pSET152ET_relA contains the relA gene. A host cell transformed by the recombinant vector is Actinomyces. A composition for enhancing antibiotics expression contains the gene or protein thereof as an active ingredient.