| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: method lies in the following: initial organic medicinal substance and auxiliary volatile substance are simultaneously evaporated in gaseous medium, which has vacuum 102 - 10-1 Pa. Obtained vapours of medicinal substance and auxiliary volatile substance are co-condensed respectively with rates 1014-51017molec/seccm2 and 31014 - 1018 molec/seccm2 respectively on precipitation surface with temperature from -196 to -50C. Surface of precipitation is inclined at angle 10-90 relative to bisector of angle, formed by vectors of components precipitation and constituting 5-170. When processes of co-condensation are over, temperature of precipitation surface is brought to temperature of surrounding medium with simultaneous removal from co-condensate of auxiliary volatile substance by pump-down in vacuum, process of pumping down auxiliary volatile substance is performed with heating precipitation surface to temperature which does not exceed 70C, with further bringing temperature of precipitation surface to temperature of surrounding medium. ^ EFFECT: invention ensures one-stage method of obtaining micronised powders of organic medicinal substances with increased rate of solubility and bioavailability. ^ 2 cl, 4 dwg, 5 ex |
