| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to chemical-pharmaceutical industry, and deals with method of obtaining highly dispersed powders of organic medicinal substances and can be used in manufacturing novel medications. Method of micronosation of N-carbamoyl-methyl-4-phenyl-2-pyrrolidone is realised by the following method. Evapouration of N-carbamoyl-methyl-4-phenyl-2-pyrrolidone is realised in neutral gaseous medium with vacuum 950-10 Pa, and precipitation of its vapours is carried out at rate 1015 - 1017 molec/seccm2 on precipitation surface, which has temperature 120 - 30C, precipitation surface being inclined at angle 15-80 relative to direction of precipitation rate vector, rate of evapouration of N-carbamoyl-methyl-4-phenyl-2-pyrrolidone exceeds rate of their precipitation in 1.2-2.5 times. Also claimed is medication, containing water-dispersive organic medicinal substance in form of micronised powder of N-carbamoyl-methyl-4-phenyl-2-pyrrolidone. ^ EFFECT: elaboration of efficient method of obtaining highly dispersive powders of organic medicinal substances. ^ 2 cl, 2 ex, 2 dwg |
