METHOD OF MIXTURE RECOVERY FOR PREPARING WATER DISPERSIONS OF SPHERICAL NANOPARTICLES

摘要

FIELD: medicine. ^ SUBSTANCE: method of mixture recovery for preparing water dispersions of spherical nanoparticles of mixed poorly water-soluble birch bark triterpenoids including injection of excess water in the birch bark triterpenoid solution in a water-mixed organic solvent to form a dispersion containing spherical nanoparticles and crystals of birch bark triterpenoids differing by the fact the produced dispersion is filtered or centrifuged with separating a fraction of the spherical nanoparticles from crystals; the separated nanoparticles are evaporated to produce a solid mixture of triterpenoids for morphologically homogeneous spherical nanoparticles by multiple injection. ^ EFFECT: high morphological uniformity of the spherical nanoparticles. ^ 2 cl, 3 ex, 2 dwg