| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: described are novel isocyanurate derivatives (1,3,5-triazine-2,4,6-triones) of formula ^ , in which 1) R1=R2=CH3, X=(CH2)n (n=1-6, 10) or CH2CH(OH)CH2 or (CH2)2O(CH2)2; 2) R1=R2=CH2=CHCH2, X=CH2CH(OH)CH2; 3) R1=CH3 or C6H5CH2; R2=X-S(O)m-CH2C(O)Y, X=(CH2)2(n=1-6); in all given formulae m=1 or 2; Y=NH2 or NHNH2. ^ EFFECT: high antituberculosis activity, as well as towards multi-drug resistant mycobacteria strains, high species specificity and low toxicity. ^ 2 cl, 5 tbl, 115 ex |
