发明名称 |
PROCESSES FOR THE ALKYLATION OF SECONDARY AMINE GROUPS OF MORPHINAN DERIVATIVES |
摘要 |
<p>The invention provides processes for the preparation of morphinans having a tertiary amine. In particular, the present invention provides processes for the formation of tertiary amine alkaloids by direct N-alkylation of secondary amine alkaloids, the processes co-mediated by an alkylating agent and a protic solvent or a mixture of a protic solvent and an aprotic solvent.</p> |
申请公布号 |
EP2344506(A2) |
申请公布日期 |
2011.07.20 |
申请号 |
EP20090789376 |
申请日期 |
2009.09.29 |
申请人 |
MALLINCKRODT INC. |
发明人 |
WANG, PETER, X.;JIANG, TAO;BERBERICH, DAVID, W. |
分类号 |
C07D489/12 |
主分类号 |
C07D489/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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