| 摘要 |
<p>The present invention relates to methods of preparing compounds of formula (I) comprising the step of reacting the corresponding amide with the corresponding substituted aryl in the presence of a catalyst, which catalyst comprises copper and a ligand, Y is CHCHR6(R7) or C=C(A)Z, CY2(R2)Y3(R3), C=N-NR4(R5); Y2 and Y3 are, independently, O, S, N; A and Z are, independently, C1-6 alkyl; R1 is CF3 or CF2H; R2 and R3 are, independently, C1-8 alkyl, wherein R2 and R3 are optionally joined to form a 5-8 membered ring; R4 and R5 are, independently, C1-8 alkyl; B is a single bond or a double bond; R6 and R7 are, independently, hydrogen or C1-6 alkyl.</p> |
