COMPOUNDS AND METHODS OF INHIBITING INTERACTION OF BCL PROTEINS WITH BINDING COMPONENTS

摘要

FIELD: chemistry. ^ SUBSTANCE: invention relates to heterocyclic compounds of formula I ^ , where Y denotes -(C=O)-, X denotes -N(R10)-, A denotes -C(A1)(A2)-, B denotes O, S, -(C=O)- or is characterised by formula ^ , where D denotes N or CR10, and where the remaining substitutes are described in the claim. Compounds of formula I, as well as composition based on said compounds can inhibit the bcl-2 family proteins. ^ EFFECT: possibility of using said compounds and compositions in treating or modulating disorders associated with hyper-proliferation, such as cancer. ^ 20 cl, 17 ex