发明名称 |
Application of 2-bromide-isovanillin for the manufacture of a medicament for anti-cancer or/and radiation/chemotherapy sensitization |
摘要 |
Use of 2-bromo-isovanillin in the preparation of an anticancer medicament and/or radio- and chemotherapy sensitizing medicament is disclosed. The medicament for the treatment of cancers and/or for radio- and chemotherapy sensitization comprising 2-bromo-isovanillin as active ingredient provided herein has the following features: (1) low toxicity, without evident adverse effects; (2) significant therapeutic effect, with remarkable proliferation inhibiting and pro-apoptotic effects in tumor cells; (3) a broad-spectrum anticancer activity; (4) suitable to be used in combination with antimetabolites, to enhance the effects and meanwhile lower the toxicity, and also to reduce multi-drug resistance; (5) convenient and safe administration, the main route being oral.
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申请公布号 |
US7981939(B2) |
申请公布日期 |
2011.07.19 |
申请号 |
US20080072496 |
申请日期 |
2008.02.25 |
申请人 |
INSTITUTE OF RADIATION MEDICINE, ACADEMY OF MILITARY MEDICAL SCIENCES, PLA |
发明人 |
ZHOU PINGKUN;YAN YUQIAN;WANG LIN;SUI JIANLI |
分类号 |
A61K31/11;A01N35/00 |
主分类号 |
A61K31/11 |
代理机构 |
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地址 |
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