发明名称 |
Diagnosis, prognosis, identification, and classification of multiple myeloma based on gene expression profiling |
摘要 |
Provided herein is a method for gene expression profiling multiple myeloma patients into distinct subgroups via DNA hybridization and hierarchical clustering analysis of the hybridization data where the results may further be used to identify therapeutic gene targets. Also provided is a method for controlling bone loss in an individual via pharmacological inhibitors of DKK1 protein. In addition provided herein is a method for diagnosing multiple myeloma using a 15-gene model that classifies myeloma into groups 1-7.
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申请公布号 |
US7983850(B2) |
申请公布日期 |
2011.07.19 |
申请号 |
US20080012302 |
申请日期 |
2008.02.01 |
申请人 |
BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS |
发明人 |
SHAUGHNESSY JOHN D.;BARLOGIE BART;ZHAN FENGHUANG |
分类号 |
G01N33/48;C12Q1/68;G01N33/50;G06F19/00;G06G7/58 |
主分类号 |
G01N33/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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