发明名称 Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
摘要 The present invention discloses novel compounds of Formula (I): having 11&bgr;-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I), as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11&bgr;-HSD type 1 activity.
申请公布号 US7981918(B2) 申请公布日期 2011.07.19
申请号 US20070297375 申请日期 2007.04.05
申请人 ELI LILLY AND COMPANY 发明人 AICHER THOMAS DANIEL;ANZEVENO PETER BIAGIO;LI RENHUA;KRASUTSKY ALEXEI PAVLOVYCH;MABRY THOMAS EDWARD;SAEED ASHRAF;SNYDER NANCY JUNE;TIAN HONGQI;WALLACE OWEN BRENDAN;WINNEROSKI LEONARD LARRY;XU YANPING
分类号 A61K31/416;C07D231/56 主分类号 A61K31/416
代理机构 代理人
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