发明名称 |
IDENTIFIKATION VON VACCINIA-VIRUS-DOMINANTEN T- ZELL-EPITOPEN |
摘要 |
<p>The present invention relates to the identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes. Two vaccinia virus CD8+ T cell epitopes restricted by the most common human MHC class I allele, HLA-A0201 have been identified. Both epitopes are highly conserved in vaccinia and variola viruses. The induction of the T cell responses following primary vaccination is demonstrated by the kinetics of epitope specific CD8+ T cells in 3 HLA-A0201 individuals. This information will be useful for the design and analyses of the immunogenicity of experimental vaccinia vaccines, and for basic studies of human T cell memory.</p> |
申请公布号 |
AT516045(T) |
申请公布日期 |
2011.07.15 |
申请号 |
AT20040705315T |
申请日期 |
2004.01.26 |
申请人 |
UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER |
发明人 |
TERAJIMA, MASANORI;CRUZ, JOHN;ENNIS, FRANCIS |
分类号 |
A61K39/285;A61K39/00;A61K39/12;A61K39/275;C07K14/07;C12Q1/70;G01N33/50;G01N33/569 |
主分类号 |
A61K39/285 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|