<p>89 5 TETOMILAST POLYMORPHS ABSTRACT THE PRESENT INVENTION PROVIDES A TETOMILAST CRYSTAL THAT IS INDUSTRIALLY EASILY PRODUCES IN A LARGE VOLUME. (1) A TETOMILAST HYDRATE CRYSTAL HAVING A POWDER X-RAY DIFFRACTION SPECTRUM THAT 10 IS SUBSTANTIALLY THE SAME AS THE POWDER X-RAY DIFFRACTION SPECTRUM SHOWN IN 2; (2) AN ANHYDROUS TETOMILAST TYPE A CRYSTAL HAVING A POWDER X-RAY DIFFRACTION SPECTRUM THAT IS SUNSTANTIALLY THE SAME AS THE POWDER X-RAY DIFFRACTION SHOWN IN 4; (3) AN ANHYDROUS TETOMILAST TYPE C CRYSTAL HAVING A POWDER X-RAY DIFFRACTION SPECTRUM THAT IS SUBSTANTIALLY THE SAME AS THE POWDER X-RAY DIFFRACTION SPECTRUM THAT IS SUBSTANTIALLY THE SAME AS THE POWDER X- I 5 RAY DIFFRACTION SPECTRUM SHOWN IN 8; (4) A TETOMILAST ACETONITRILE SOIVATE CRYSTAL HAVING A POWDER X-RAY DIFFRACTION SPECTRUM THAT IS SUBSTANTIALLY THE SAME AS THE POWDER X-RAY DIFFRACTION SPECTRUM SHOWN IN IO; AND (5) A MIXTURE CONSISTING OF THE ABOVE ANHYDROUS TETOMILAST TYPE A CRYSTAL AND AN ANHYDROUS TETOMILAST TYPE B CRYSTAL. THESE CRYSTAL ARE STABLE TOWARDS BEAT AND MOISTURE, AND ARE ALSO EXCELLENT IN TERMS OF THE DISINTEGRATION PROPERTY AND 20 DISSOLUTION PROPERTY OF TABLETS. ACCORDINGLY, THESE CRYSTALS ARE PREFERABLY USED AS PHARMACEUTICAL COMPOSITIONS.</p>
