发明名称 |
REKOMBINANTE PRODUKTION VON ANTIKÖRPERMISCHUNGEN |
摘要 |
The invention provides methods for producing mixtures of antibodies from a single host cell clone. Thereto, a nucleic acid sequence encoding a common light chain, and nucleic acid sequences encoding two different heavy chains are expressed in a recombinant host cell. The antibodies in mixtures according to the invention comprise two different heavy chains capable of pairing to a common light chain, thereby forming functional antigen binding domains. Mixtures of antibodies, and use of these mixtures in a variety of field, are also provided by the invention. |
申请公布号 |
AT514717(T) |
申请公布日期 |
2011.07.15 |
申请号 |
AT20030764997T |
申请日期 |
2003.07.15 |
申请人 |
MERUS B.V. |
发明人 |
VAN BERKEL, PATRICK;BRUS, RONALD;BOUT, ABRAHAM;LOGTENBERG, TON |
分类号 |
C07K16/46;A61K39/00;C07K14/00;C07K16/00;C07K16/10;C07K16/28;C07K16/30;C07K16/32;C12N15/00;C12P21/02 |
主分类号 |
C07K16/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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