摘要 |
<p>Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with a death receptor ligand, which method comprises contacting the cancer cells with a death receptor ligand in conjunction with an effective amount of a compound described herein, for example, a cucurbitacin (I) or a withanolide (II). Also disclosed is a method of inducing apoptosis in cancer cells in a mammal, comprising contacting the cancer cells with a compound described herein, for example, a cucurbitacin (I) or a withanolide (II) and also contacting the cancer cells with a death receptor ligand, whereby apoptosis is induced in the cancer cells.</p> |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;SAYERS, THOMAS, JOSEPH;BOOTH, NANCY, LYNN;HENRICH, CURTIS J.;BROOKS, ALAN, DAVID;GUSTAFSON, KIRK, R.;ERICKSON, KAREN, L. |
发明人 |
SAYERS, THOMAS, JOSEPH;BOOTH, NANCY, LYNN;HENRICH, CURTIS J.;BROOKS, ALAN, DAVID;GUSTAFSON, KIRK, R.;ERICKSON, KAREN, L. |