发明名称 |
METHOD AND COMPOSITION FOR RNA INTERFERENCE |
摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for attenuating the expression of a target gene in a host cell. <P>SOLUTION: The method includes introducing double stranded RNA (dsRNA) into the host cells in an amount sufficient to attenuate the expression of the target gene, wherein the dsRNA comprises a nucleotide sequence that hybridizes under stringent conditions to an untranslated sequence of the target gene. Compositions thereof and pharmaceutical preparations are also provided. <P>COPYRIGHT: (C)2011,JPO&INPIT |
申请公布号 |
JP2011135882(A) |
申请公布日期 |
2011.07.14 |
申请号 |
JP20110021889 |
申请日期 |
2011.02.03 |
申请人 |
COLD SPRING HARBOR LAB |
发明人 |
BERNSTEIN EMILY;CAUDY AMY;HANNON GREGORY J;PADDISON PATRICK J;CONKLIN DOUGLAS |
分类号 |
C12N15/09;G01N33/50;A01K67/027;A61K31/7088;A61K31/7105;A61K35/28;A61K38/00;A61K48/00;A61P31/00;A61P31/18;C12N5/10;C12N15/10;C12N15/11;C12N15/113;C12Q1/02;C12Q1/68;G01N33/15 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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