发明名称 METHOD AND COMPOSITION FOR RNA INTERFERENCE
摘要 <P>PROBLEM TO BE SOLVED: To provide a method for attenuating the expression of a target gene in a host cell. <P>SOLUTION: The method includes introducing double stranded RNA (dsRNA) into the host cells in an amount sufficient to attenuate the expression of the target gene, wherein the dsRNA comprises a nucleotide sequence that hybridizes under stringent conditions to an untranslated sequence of the target gene. Compositions thereof and pharmaceutical preparations are also provided. <P>COPYRIGHT: (C)2011,JPO&INPIT
申请公布号 JP2011135882(A) 申请公布日期 2011.07.14
申请号 JP20110021889 申请日期 2011.02.03
申请人 COLD SPRING HARBOR LAB 发明人 BERNSTEIN EMILY;CAUDY AMY;HANNON GREGORY J;PADDISON PATRICK J;CONKLIN DOUGLAS
分类号 C12N15/09;G01N33/50;A01K67/027;A61K31/7088;A61K31/7105;A61K35/28;A61K38/00;A61K48/00;A61P31/00;A61P31/18;C12N5/10;C12N15/10;C12N15/11;C12N15/113;C12Q1/02;C12Q1/68;G01N33/15 主分类号 C12N15/09
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