发明名称 |
POLYPEPTIDE OR FUSED PROTEIN THEREOF INHIBITING THE EXTRAVASATION OF WHITE BLOOD CELLS OR THE GROWTH AND/OR METASTASIS OF CANCER CELLS |
摘要 |
The present invention relates to a polypeptide derived from a highly conserved region (HCR) I-III of an extracellular region of a CD99 and CD99 family such as CD99L2 and PBDX (or XG), which are a kind of transmembrane protein, or a fused protein thereof. The polypeptide or the fused protein thereof has an activating function of inhibiting the extravasation of white blood cells, or inhibiting the growth and/or metastasis of cancer cells. The present invention also provides a polynucleotide coding the polypeptide, a vector including same, and a transformant transformed by the vector. In addition, the present invention provides a pharmaceutical composition including the polypeptide or the fused protein thereof for preventing or treating inflammatory diseases. Further, the present invention provides a pharmaceutical composition including the polypeptide or the fused protein thereof inhibiting the growth and/or metastasis of cancer cells, i.e., a pharmaceutical composition for preventing or treating cancer. |
申请公布号 |
WO2011049289(A3) |
申请公布日期 |
2011.07.14 |
申请号 |
WO2010KR05619 |
申请日期 |
2010.08.24 |
申请人 |
SUPADELIXIR INC.;HAHN, JANG-HEE;LEE, KYOUNG-JIN;LEE, SUN-HEE;JU, HYUN-MI |
发明人 |
HAHN, JANG-HEE;LEE, KYOUNG-JIN;LEE, SUN-HEE;JU, HYUN-MI |
分类号 |
A61K38/16;A61P35/00;A61P35/04 |
主分类号 |
A61K38/16 |
代理机构 |
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