NOVEL ANTI-INFLAMMATORY PEPTIDES THAT BIND OXIDIZED PHOSPHOLIPIDS

摘要

Oxpholipin peptides are a family of peptides that have potent properties attributable to their lipid binding properties. Oxpholipin peptides may be administered orally or parenterally to remove cholesterol and/or oxidized phospholipids from the serum, and from vascular and nonvascular tissue sites. In certain embodiments oxpholipin peptides are administered in combination with a second agent, e.g. statins, ApoAI peptides, etc. The peptides also possess also anti-inflammatory properties as determined by in vitro monocyte chemotactic assay (MCA) and their activity is carried on into relevant in vivo system of ApoE deficient mice. Surface plasmon resonance (SPR) studies revealed that the most potent anti-inflammatory compound, OxP-11D binds with high affinity to various oxidized phospholipids and sterols.