| 发明名称 |
HUMANIZED MONOCLONAL ANTIBODIES AND METHODS OF USE |
| 摘要 |
The present invention comprises a humanized monoclonal antibody that binds to the chemokine receptor CCR4. This antibody is derived from Mab 1567 and recognizes the same epitope. Binding of the invented antibody to CCR4 inhibits ligand-mediated activities and is used to treat symptoms of cancer. Moreover, the antibody is used in combination with vaccines to suppress the activity of regulatory T cells.
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| 申请公布号 |
US2011171210(A1) |
申请公布日期 |
2011.07.14 |
| 申请号 |
US20080810888 |
申请日期 |
2008.12.29 |
| 申请人 |
DANA-FARBER CANCER INSTITUTE, INC.;THE BRIGHAM AND WOMEN'S HOSPITAL, INC. |
发明人 |
MARASCO WAYNE;SUI JIANHUA;ZHU QUAN;KUPPER THOMAS |
| 分类号 |
A61K39/395;A61P31/04;A61P31/12;A61P31/18;A61P35/00;A61P35/02;A61P37/04;C07H21/00;C07K16/28;C12N5/07;C12N5/0783;C12N5/09;C12N5/10;C12N15/63 |
主分类号 |
A61K39/395 |
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