BOROSILICATE GLASSWARE AND SILICA BASED QMA'S IN 18F NUCLEOPHILIC SUBSTITUTION: INFLUENCE OF ALUMINUM, BORON AND SILICON ON THE REACTIVITY OF THE 18F ION

摘要

Aluminum, boron and silicon were identified as potential leachables from borosilicate glassware and a silica based QMA during handling of aqueous 18F. The addition of only 0.4 ppm aluminum as A1C13 in the eluent vial resulted in a strong reduction in the labeling yield of a model [18F]fluoride SN2 reaction (from 80 to 40 % incorporation). The addition of boron as KBO2 and silicon as NaSiO3 did not result in any significant decrease in labeling yield. Interestingly, there was an interaction effect between A1C13 and KBO2 in which the negative effect from A1C13 on labeling yield was counteracted by KBO2. The present invention demonstrates that aluminum and boron from borosilicate glassware have a strong influence on the labeling yield in nucleophilic SN2 reactions with n.c.a [18F]fluoride.