COMPOUNDS AND THEIR USE

摘要

The invention provides compounds of Formula (1); wherein: R1 represents C1-6 alkyl or H; X represents N or CH; Y represents -NR2R3 as depicted in Formula (A), or a ring of formula (B); wherein a represents the point of attachment to the pyridinyl or pyrazinyl ring; R2 represents C1-6 alkyl optionally substituted by haloC1-3 alkyl or C1-4 alkoxy; R3 represents H, C1-6 alkyl or C3-8 heterocyclyl; W represents -(CH2)n-; W) represents -(CH2)P-; n represents 1, 2 or 3;, p represents 1 or 2; R4 represents halogen or C1-4 alkoxy; and R5 represents H or halogen; R6 represents H or C1-6 alkyl;provided that, when X represents CH and R2 is C1-3 alkyl, R1 is not H; and provided that, when X represents CH and R4 represents halogen, R5 is not H; or a pharmaceutically acceptable salt thereof. The compounds of the invention have been found to modulate the histamine H3 receptor.