发明名称 |
A METHOD FOR THE PREPARATION OF 6,7-DIMETHOXY-1-[2-(4-TRIFLUOROMETHYLPHENYL)ETHYL]-3,4- DIHYDROISOQUINOLINE |
摘要 |
<p>The invention relates to a method of preparing 6,7-dimethoxy-l-[2-(4-trifluoromethylphenyl) ethyl]-3,4-dihydroisoquinoline I by cyclization of substance III, wherein the R substituent is a C1-C4 alkyl group, under conditions of acidic catalysis, the acidic catalyst being a strong inorganic acid, polyphosphoric acid or phosphorus oxychloride. The compound of formula (I) represents the key intermediate of synthesis of almorexant. (Formulae (I), (III))</p> |
申请公布号 |
WO2011082700(A1) |
申请公布日期 |
2011.07.14 |
申请号 |
WO2011CZ00001 |
申请日期 |
2011.01.05 |
申请人 |
ZENTIVA, K.S.;RADL, STANISLAV;CERNY, JOSEF |
发明人 |
RADL, STANISLAV;CERNY, JOSEF |
分类号 |
C07D217/18 |
主分类号 |
C07D217/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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