Binding proteins specific for insulin-like growth factors and uses thereof

摘要

Abstract Binding proteins, such as antibodies directed to IGF-II with cross-reactivity to IGF-I and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the IGF-II with cross-reactivity to IGF-I are disclosed. Also discussed are nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FRI through FR4 or CDRl through CDR3. 0).) Z 3 9~Ic C C C6 J no) I~t U)la M U.)U 2~~~~ a) =~.E.O).O.0) 2 o ho0 I-D Cjs 0 0n c') 0~ 0) 0 0D 0 0 0 0 0 0 C) C> 0 0 0 (0DCDC (cww) 9wflIOA JoUfjL ue8yq