发明名称 |
HUMANIZED FCYR MICE |
摘要 |
<p>Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity Fc?R locus, and wherein the mouse is capable of expressing a functional FcR?-chain. Genetically modified mice are described, including mice that express low affinity human Fc?R genes from the endogenous Fc?R locus, and wherein the mice comprise a functional FcR?-chain. Genetically modified mice that express up to five low affinity human Fc?R genes on accessory cells of the host immune system are provided.</p> |
申请公布号 |
CA2784953(A1) |
申请公布日期 |
2011.07.14 |
申请号 |
CA20102784953 |
申请日期 |
2010.12.17 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
MACDONALD, LYNN;TU, NAXIN;GURER, CAGAN;STEVENS, SEAN;MURPHY, ANDREW J. |
分类号 |
A01K67/027;C07K14/735;C12N15/00;C12N15/12;C12Q1/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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