| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide vascular endothelial cell growth factor (VEGF) antagonists, therapeutic compositions comprising the antagonists and methods of use of the antagonists for diagnostic and therapeutic purposes. <P>SOLUTION: The antagonists include: (a) antibodies and variants thereof which are capable of specifically binding to hVEGF, hVEGF receptor, or a complex comprising hVEGF in association with hVEGF receptor; (b) hVEGF receptor and variants thereof; and (c) hVEGF variants. The antagonists inhibit, sequester or neutralize the mitogenic, angiogenic, vascular permeability or other biological activity of hVEGF, and thus are useful for the treatment of diseases or conditions characterized by undesirable excessive neovascularization, in particular, for that of edema or stroke. <P>COPYRIGHT: (C)2011,JPO&INPIT</p> |
