发明名称 |
Enhanced Cytotoxicity of Anti-CD74 and Anti-HLA-DR Antibodies with Interferon-Gamma |
摘要 |
Disclosed herein are methods and compositions comprising interferon-γ (IFN-γ) and anti-CD74 or anti-HLA-DR antibodies. In preferred embodiments, the IFN-γ increases the expression of CD74 and/or HLA-DR in target cells and increases the sensitivity of the cells to the cytotoxic effects of the anti-CD74 or anti-HLA-DR antibodies. The compositions and methods are of use to treat diseases involving CD74+ and/or HLA-DR+ cells, such as cancer cells, autoimmune disease cells or immune dysfunction disease cells.
|
申请公布号 |
US2011171126(A1) |
申请公布日期 |
2011.07.14 |
申请号 |
US201113004349 |
申请日期 |
2011.01.11 |
申请人 |
CENTER FOR MOLECULAR MEDICINE AND IMMUNOLOGY;IMMUNOMEDICS, INC. |
发明人 |
BURTON JACK D.;STEIN RHONA;GOLDENBERG DAVID M. |
分类号 |
A61K38/20;A61K38/21;A61K51/00;A61K51/10;A61P35/00;A61P37/00 |
主分类号 |
A61K38/20 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|