发明名称 SITE-SPECIFIC ATTACHMENT OF DRUGS OR OTHER AGENTS TO ENGINEERED ANTIBODIES WITH C-TERMINAL EXTENSIONS
摘要 The present invention provides antibodies (e.g., IgG antibodies) having C-terminal cysteine-containing extensions that facilitate antibody conjugation to a partner molecule (e.g. a drug, toxin, marker molecule, protein, radioisotope, or other therapeutic agent). Methods of making, screening and selecting the antibodies of the invention are provided.
申请公布号 EP2185188(A4) 申请公布日期 2011.07.13
申请号 EP20080798164 申请日期 2008.08.19
申请人 MEDAREX, INC. 发明人 LIU, JIE;KING, DAVID
分类号 A61K39/00 主分类号 A61K39/00
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