| 摘要 |
<p>The present invention is to provide manufacturing intermediates which can be led to useful α-ketoamide compounds having protease-inhibiting activity extremely economically and stereoselectively, and to provide amino alcohol compounds represented by the following formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="22" wi="93" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry>
wherein R<Sup>1</Sup> and R<Sup>2</Sup> each represents alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group; R<Sup>3</Sup> represents alkyl group, alkenyl group, aromatic hydrocarbon group, heterocyclic group, R<Sup>6</Sup>-O- or R<Sup>7</Sup>-N(R<Sup>8</Sup>)-; where R<Sup>6</Sup> represents alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group; R<Sup>7</Sup> and R<Sup>8</Sup> each represents hydrogen atom, alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group, and, R<Sup>4</Sup> and R<Sup>5</Sup> represent the same groups as R<Sup>7</Sup> and R<Sup>8</Sup>, respectively, and R<Sup>9</Sup> and R<Sup>5</Sup> optionally form a ring together; and X represents -O- or -N(R<Sup>9</Sup>)-, where R<Sup>9</Sup> represents hydrogen atom or alkyl group, and X optionally forms a ring together with R<Sup>4</Sup> or R<Sup>5</Sup>,
and processes for preparing α-keto amide compound using the same.</p> |
