| 发明名称 |
ISOLATED DNA ENCODING HUMAN H3 HISTAMINE RECEPTOR |
| 摘要 |
DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNAs have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
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| 申请公布号 |
CA2312274(C) |
申请公布日期 |
2011.07.12 |
| 申请号 |
CA19982312274 |
申请日期 |
1998.10.07 |
| 申请人 |
ORTHO-MCNEIL PHARMACEUTICAL, INC. |
发明人 |
LOVENBERG, TIMOTHY W.;ERLANDER, MARK;HUVAR, ARNE;PYATI, JAYASHREE |
| 分类号 |
C12N15/12;G01N33/50;A61K31/00;A61K31/785;A61K38/00;A61K45/00;A61P3/04;A61P3/10;A61P9/06;A61P25/00;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;C07K14/705;C07K14/72;C07K16/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/63;C12P21/02;C12Q1/02;C12Q1/68;G01N33/15;G01N33/566 |
主分类号 |
C12N15/12 |
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