| 摘要 |
A device and method is described for photodynamic therapy (PDT) to treat hyperproliferative tissue growth in an underskin area within a few centimeters of the skin surface that is not accessible by conventional topical irradiation. The device comprises a plate having an array of openings with hollow micro-needles mounted therein that extend to a specified length on each side. Optical fibers are individually threaded through the micro-needles from the side opposite the treatment area and may be kept together as a bundle for attachment to a laser radiation source. The optical fibers have output ends made to provide a uniform radiation pattern to the underlying tissue. A photosensitizer is administered either systemically or locally and allowed a sufficient time to diffuse into the area of treatment. The laser of selected wavelength is coupled to the fiber bundle which then directs the radiation through the optical fibers to the treatment site.
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