| 发明名称 |
LOW-CALCEMIC OXIME ANALOGS OF 1.ALPHA.,25-DIHYDROXY VITAMIN D3 |
| 摘要 |
The present invention provides novel 16-ene-C25-oxime and 16-ene-C-25-oxime ether analogs of 1.alpha.,25-dihydroxy vitamin D3, compositions comprising these compounds and methods of using these compounds as inhibitors of CYP24. In particular, the compound of Formula I are useful for treating diseases which benefit from a modulation of the levels of 1.alpha.,25-dihydroxy vitamin D3, for example, cell-proliferative disorders.
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| 申请公布号 |
CA2463505(C) |
申请公布日期 |
2011.07.12 |
| 申请号 |
CA20022463505 |
申请日期 |
2002.10.11 |
| 申请人 |
JOHNS HOPKINS UNIVERSITY;CYTOCHROMA INC. |
发明人 |
POSNER, GARY H.;WHITE, JAY A.;JONES, GLENVILLE;HALFORD, BETHANY;KAHRAMAN, MEHMET;JEON, HEUNG BAE |
| 分类号 |
A61K45/00;C07C401/00;A61K31/59;A61K31/593;A61P3/02;A61P3/10;A61P3/14;A61P5/00;A61P5/14;A61P13/08;A61P17/00;A61P17/02;A61P17/06;A61P19/08;A61P19/10;A61P31/06;A61P35/00;A61P43/00 |
主分类号 |
A61K45/00 |
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