发明名称 |
Antibody molecules specific to human tumour necrosis factor alpha |
摘要 |
There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNFα. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNFα.
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申请公布号 |
US7977464(B2) |
申请公布日期 |
2011.07.12 |
申请号 |
US20080141667 |
申请日期 |
2008.06.18 |
申请人 |
UCB PHARMA S.A. |
发明人 |
ATHWAL DILJEET SINGH;BROWN DEREK THOMAS;WEIR ANDREW NEIL CHARLES;POPPLEWELL ANDREW GEORGE;CHAPMAN ANDREW PAUL;KING DAVID JOHN |
分类号 |
C12N15/09;C12P21/08;A61K39/395;A61K47/48;A61P19/02;A61P29/00;A61P37/06;C07H21/04;C07K16/00;C07K16/24;C07K16/46;C12N1/21;C12N15/13;C12P21/02;C12P21/04 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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