发明名称 SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS
摘要 , (I)The present invention relates to novel compounds selected from substituted oxazole derivatives of formula (I) that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective c-kit, bcr-abl and Flt-3 inhibitors.
申请公布号 UA95071(C2) 申请公布日期 2011.07.11
申请号 UA20070012205 申请日期 2006.04.04
申请人 AB SCIENCE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);INSTITUT CURIE 发明人 GRIERSON DAVID;BENJAHAD ABDELLAH;MOUSSY, ALAIN;CROISY MARTINE
分类号 A61K31/421;A61K31/427;A61K31/4439;C07D263/48;C07D413/04;C07D413/12;C07D413/14;C07D417/12 主分类号 A61K31/421
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