METHOD FOR SYNTHESIZING AND PREPARING EPTIFIBATIDE
摘要
<p>The present invention provides a method for synthesizing eptifibatide. Specific steps of this method are as follows: (1) synthesizing peptide fragment 1 by liquid phase synthesis: Mpr (X)-Har (R4)-Gly-OH; (2) synthesizing peptide fragment 2 by liquid phase synthesis: R1-Asp (R2)-Trp (R3)-Pro-Cys (Y)-NH2; (3) condensing peptide fragment 1 and peptide fragment 2 and preparing fully-protected peptide fragment 3: Mpr (X)-Har (R4)-Gly-Asp (R2)-Trp (R3)-Pro-Cys (Y)-NH2; (4) removing protective group from peptide fragment 3 to obtain a linear peptide: Mpr (X)-Har-Gly-Asp-Trp-Pro-Cys (Y)-NH2; (5) oxidizing the linear peptide to form disulfide bridge bond to obtain eptifibatide (I).</p>
