RECOMBINANT ADENOVIRUS HAVING ANTI-ANGIOGENESIS ACTIVITY

摘要

The present invention relates to a recombinant adenovirus with improved angiogenesis inhibition activity and to a pharmaceutical composition comprising the recombinant adenovirus for inhibiting angiogenesis. The recombinant adenovirus comprises: (a) a nucleotide sequence of inverted terminal repeats (ITRs) of an adenovirus; and (b) a nucleotide sequence for coding a chimeric decoy receptor containing (i) an extracellular domain of vascular endothelial growth factor receptor 1 (VEGFR-1), and (ii) an extracellular domain of vascular endothelial growth factor receptor 2 (VEGFR-2). The recombinant adenovirus which expresses the chimeric decoy receptor according to the present invention inhibits angiogenesis in a significantly effective manner, and can be used for gene therapy for various angiogenesis-related diseases. Particularly, the recombinant adenovirus of the present invention has superior cytotoxicity for tumor cells.