PREPARATION METHOD OF SOLID FORMULATIONS AND SOLID FORMULATIONS PREPARED THEREBY

摘要

A preparation method of solid formulations and the solid formulations prepared thereby are disclosed. The method comprises the steps of: dissolving insoluble or slightly soluble basic active ingredients in an acid solution comprising acidifiers, then homogenously mixing basifiers and adjuvants with the acidic solution comprising active ingredients, and granulating by wetting granulation method. The basifiers are the agents which can reduce the acidity of the mixed solution of the basifiers and the acidic solution.