<p>Disclosed are novel compounds having NPR-B agonistic activity. Preferred compounds are linear peptides containing 8-13 conventional or non-conventional L- or D- amino acid residues connected to one another via peptide bonds. Also disclosed are methods of treating C-type natriuretic peptide (CNP)-mediated disorders, including glaucoma and/or elevated intraocular pressure, in a subject using pharmaceutical compositions that include a novel NPR-B agonist as described herein.</p>
申请公布号
WO2011038066(A4)
申请公布日期
2011.07.07
申请号
WO2010US49917
申请日期
2010.09.23
申请人
ALCON RESEARCH, LTD.;HELLBERG, MARK R.;PANG, IOK-HOU