发明名称 |
Secretion Optimized Microorganism |
摘要 |
Proteins having a cofactor can be secreted in an improved manner in a microorganism belonging to the genus Streptomyces provided that the microorganism contains a nucleic acid sequence which is not naturally present in it and which comprises at least the following sequence sections: a) nucleic acid sequence coding for a protein containing a cofactor, and b) a nucleic acid sequence which is at least 20% identical to the sequence given in SEQ ID NO. 1, or at least 20% identical to the sequence given in SEQ ID NO. 3, or a nucleic acid sequence which is structurally homologous to at least one of these sequences, wherein the amino acid sequence encoded by nucleic acid sequence b) functionally cooperates with the amino acid sequence encoded by nucleic acid sequence a) so that at least the amino acid sequence encoded by nucleic acid sequence a) is secreted by the microorganism.
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申请公布号 |
US2011165619(A1) |
申请公布日期 |
2011.07.07 |
申请号 |
US20100955353 |
申请日期 |
2010.11.29 |
申请人 |
BONGAERTS JOHANNES;EVERS STEFAN;FOH KERSTIN;MAURER KARL-HEINZ |
发明人 |
BONGAERTS JOHANNES;EVERS STEFAN;FOH KERSTIN;MAURER KARL-HEINZ |
分类号 |
C12P21/02;C12N1/00;C12N1/21;C12N9/02;C12N9/08;C12N9/16;C12N9/28;C12N9/42;C12N9/52 |
主分类号 |
C12P21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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