发明名称 |
ACTIVATION AND ACTIVATORS OF SIRT5 |
摘要 |
The invention provides a method of increasing a deacetylase activity of SIRT5 by contacting SIRT5 with an agent that binds SIRT5 and reduces the Km of SIRT5 for a substrate, thereby increasing the deacetylase activity of SIRT5. The invention also provides a method for treating a urea cycle disorder in a mammal, as well as a method of assaying a sirtuin modulator. |
申请公布号 |
WO2011081942(A1) |
申请公布日期 |
2011.07.07 |
申请号 |
WO2010US60334 |
申请日期 |
2010.12.14 |
申请人 |
CORNELL UNIVERSITY;SAUVE, ANTHONY;CEN, YANA |
发明人 |
SAUVE, ANTHONY;CEN, YANA |
分类号 |
A61K45/06;A61K31/341;A61K31/443;A61P3/00;C40B40/10 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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