| 摘要 |
The present invention provides processes useful for preparing 5-lipoxygenase activating protein (FLAP) inhibitors and their intermediates. In particular, processes for preparing 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid, the anhydrous Form C polymorph of sodium 3-[3- (tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H- indol-2-yl]-2,2-dimethyl-propionate, and intermediates useful in said processes are provided. |
| 申请人 |
GLAXO GROUP LIMITED;AMIRA PHARMACEUTICALS, INC.;CRAWFORD, CLAIRE FRANCES;GARCIA, SANDRINE;GRAHAM, JONATHAN PAUL;HARLING, SANDRA JANE;HENLEY, NICHOLAS PAUL;HERMITAGE, STEPHEN ANDREW;HUTCHINSON, JOHN HOWARD;KEEL, TREVOR RAYMOND;KENNEDY, ANDREW;MASON, ANDREW MCMURTRIE;SCOTT, MARK SIMON;SMITH, NEIL MICHAEL;STOCK, NICHOLAS SIMON;TATENO, YUICHI;TROUW, LEONTINE SASKIA;TURNER, PETER GRAHAM;WALLIS, CHRISTOPHER JOHN;WILLACY, ROBERT DAVID |
发明人 |
CRAWFORD, CLAIRE FRANCES;GARCIA, SANDRINE;GRAHAM, JONATHAN PAUL;HARLING, SANDRA JANE;HENLEY, NICHOLAS PAUL;HERMITAGE, STEPHEN ANDREW;HUTCHINSON, JOHN HOWARD;KEEL, TREVOR RAYMOND;KENNEDY, ANDREW;MASON, ANDREW MCMURTRIE;SCOTT, MARK SIMON;SMITH, NEIL MICHAEL;STOCK, NICHOLAS SIMON;TATENO, YUICHI;TROUW, LEONTINE SASKIA;TURNER, PETER GRAHAM;WALLIS, CHRISTOPHER JOHN;WILLACY, ROBERT DAVID |
