FGF RECEPTOR-ACTIVATING N-SULFATE OLIGOSACCHARIDES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF

摘要

The invention relates to FGF receptor-activating N-sulfate oligosaccharides having Formula (I), wherein R1, R4, R6, and R8 are -OSO3- or hydroxyl groups, R2 is an -O-alkyl group or a monosaccharide having Formula (II), R3 is a disaccharide having Formula (III), R5 is a disaccharide having Formula (IV), R7 is a hydroxyl group or a disaccharide having Formula (VI), and R9 is a hydroxyl or -O-alkyl group or a disaccharide having Formula (VII), where R10 is an -O-alkyl group. The invention further relates to the preparation of said oligosaccharides and to the therapeutic use thereof.