| 发明名称 |
IMPROVED EXPRESSION OF IL-12 FAMILY HETERODIMERS |
| 摘要 |
The present invention provides methods of improving the levels and stability of expression of interleukin-12 family cytokine polypeptides by expressing the alpha and beta subunits of the polypeptides at their determined relative molar ratios that increase the levels and stability of expression of the heterodimer, e.g., in comparison to heterodimer expressed at an equimolar ratio. |
| 申请公布号 |
US2011166210(A1) |
申请公布日期 |
2011.07.07 |
| 申请号 |
US20090992077 |
申请日期 |
2009.05.11 |
| 申请人 |
THE GOVT. OF THE U.S.A. AS REPRESENTED BY THE SEC. OF THE DEPT. OF HEALTH AND HUMAN SERVICES |
发明人 |
FELBER BARBARA K.;PAVLAKIS GEORGE N. |
| 分类号 |
A61K31/7088;C07H21/04;C12N5/10;C12N15/63;C12P21/02 |
主分类号 |
A61K31/7088 |
| 代理机构 |
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