发明名称 |
TUMOR CELLS FROM IMMUNE PRIVILEGED SITES AS BASE CELLS FOR CELL-BASED CANCER VACCINES |
摘要 |
The present invention relates to tumor cell-based vaccines and methods of using same, wherein the vaccines are based on naturally immune privileged tumor cells that have been genetically modified to express MHC-II restricted peptides derived from endogenously encoded tumor antigens, activate CD4+ T-lymphocytes, provide an array of antigens to which the host is not tolerized and/or induce immunity against the originating tumor cells as well as against metastatic tumor cells.
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申请公布号 |
US2011165187(A1) |
申请公布日期 |
2011.07.07 |
申请号 |
US20100889043 |
申请日期 |
2010.09.23 |
申请人 |
OSTRAND-ROSENBERG SUZANNE;BOSCH JACOBUS J;KSANDER BRUCE R |
发明人 |
OSTRAND-ROSENBERG SUZANNE;BOSCH JACOBUS J.;KSANDER BRUCE R. |
分类号 |
A61K39/21;A61K39/00;A61M31/00;A61P35/00;A61P35/04;A61P37/04;C12N15/85;C12N15/867 |
主分类号 |
A61K39/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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