发明名称 |
IDENTIFICATION OF PREDICTIVE MARKERS OF RESPONSE TO DASATINIB IN HUMAN COLON CANCER |
摘要 |
Methods and compositions are provided useful in the diagnosis, treatment and management of cancers wherein cancer cells express certain polynucleotides and/or polypeptides that are differentially expressed in colon cancer subtypes that are sensitive to therapy with abl kinase inhibitors and src kinase inhibitors. In particular, PTK-7, PLK-2 and PLK-3 could be identified as markers for determining the responsiveness of cancer to dasatinib.
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申请公布号 |
US2011166154(A1) |
申请公布日期 |
2011.07.07 |
申请号 |
US20090863207 |
申请日期 |
2009.01.23 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
SLAMON DENNIS J.;FINN RICHARD S.;DERING JUDY;HECHT J. RANDOLPH;WAINBERG ZEV A.;CLARK EDWIN A.;GINTHER CHARLES L. |
分类号 |
A61K31/506;A61P35/00;C12Q1/02;C12Q1/68 |
主分类号 |
A61K31/506 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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