PREPARATION METHOD FOR 3-?-ARACHIDYLAMIDO-7?,12?,5?-CHOLAN-24-CARBOXYLIC ACID

摘要

A method for preparing 3-ß-arachidylamido-7a,12a,5ß-cholan-24-carboxylic acid represented by the following formula V is disclosed, which comprises the following steps: converting cholic acid to the compound of formula III by acylation reaction and azidation reaction, reducing the compound of formula III to the compound of formula IV and in the end acylating the compound of formula IV with arachidoyl chloride to get the compound of formula V. The method avoids the use of protection groups.