发明名称 |
METHOD FOR GENERATING ACTIVATED T-CELLS AND ANTIGEN-PULSED ANTIGEN-PRESENTING CELLS |
摘要 |
A method for generating a mixture of activated T-cells by combining a plurality of peripheral blood lymphocytes (PBLS) with an antigen-loaded liposome to produce antigen-loaded PBLs, and combining the antigen-loaded PBLs with a naive, anergic or memory T-cell, to produce an activated T-cell. Such activation is carried out in vivo or in vitro, The antigen-loaded PBLs and activated T-cells, prepared according to the methods of invention, have use as cellular vaccines for treatment of cancer and viral diseases. |
申请公布号 |
EP2341072(A2) |
申请公布日期 |
2011.07.06 |
申请号 |
EP20100180388 |
申请日期 |
1998.05.07 |
申请人 |
ONCOTHYREON INC. |
发明人 |
AGRAWAL, BABITA;KRANTZ, MARK J;REDDISH, MARK A;LONGENECKER, MICHAEL B |
分类号 |
C07K14/47;C12N5/06;A61K9/127;A61K35/26;A61K39/00;A61P35/00;C07K7/06;C07K14/82;C12N5/08 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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