发明名称 |
Inhibitors of serine proteases, particularly HCV NS3-NS4a protease |
摘要 |
<p>The present invention relates to compounds of formula I or formula Ia or pharmaceutically acceptable salts thereof, that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are useful as antiviral agents. The invention further relates to pharmaceutically acceptable compositions comprising said compounds either for ex vivo use or for administration to a patient suffering from HCV infection and processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a pharmaceutical composition comprising a compound of this invention.</p> |
申请公布号 |
EP2341065(A2) |
申请公布日期 |
2011.07.06 |
申请号 |
EP20100176709 |
申请日期 |
2004.07.16 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
BRITT, SHAWN, D.;COTTRELL, KEVIN M.;PERNI, ROBERT B.;PITLIK, JANOS |
分类号 |
C07K5/10;A61K38/04;A61P31/12;C07K7/06 |
主分类号 |
C07K5/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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