| 摘要 |
<p>The sequences for the surface coat proteins from Clostridium difficile (CotA, CotB, CotC, CotD and CotE, SEQ ID No 1-5) are disclosed. The uses of these nucleic acids and proteins as antigens for use in vaccine design and construction and to vaccines per se, and in diagnostic test kits and methods for the detection of Clostridium spp and of Bacillus spp infections is disclosed. In addition, the nucleic acids and proteins can be used as potential targets for therapeutic drugs for the prevention or treatment of Clostridium spp. infections.</p> |
