发明名称 |
Reducing the immunogenicity of fusion proteins |
摘要 |
Disclosed are compositions and methods for producing fusion proteins with reduced immunogenicity. Fusion proteins of the invention include a junction region having an amino acid change that reduces the ability of a junctional epitope to bind to MHC Class II, thereby reducing its interaction with a T-cell receptor. Methods of the invention involve analyzing, changing, or modifying one or more amino acids in the junction region of a fusion protein in order to identify a T-cell epitope and reduce its ability to interact with a T cell receptor. Compositions and methods of the invention are useful in therapy.
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申请公布号 |
US7973150(B2) |
申请公布日期 |
2011.07.05 |
申请号 |
US20090552076 |
申请日期 |
2009.09.01 |
申请人 |
MERCK PATENT GMBH |
发明人 |
GILLIES STEPHEN D.;WAY JEFFREY;HAMILTON ANITA A. |
分类号 |
C07H21/04;C12N15/09;A61K38/00;A61K38/22;A61K38/24;A61K38/27;A61K45/00;A61K47/00;C07K1/00;C07K14/00;C07K14/505;C07K14/52;C07K14/54;C07K14/55;C07K14/575;C07K14/705;C07K14/725;C07K14/76;C07K16/00;C07K16/18;C07K17/00;C07K19/00;C12N15/62;G01N33/53 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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